Misfits follows five outsiders on community service who get struck by a flash storm and lumbered with special powers.
Robert Sheehan (Nathan), BAFTA-nominee Lauren Socha (Kelly), Nathan Stewart-Jarrett (Curtis), Antonia Thomas (Alisha) and Iwan Rheon (Simon) will be on hand to discuss the comedy drama.
The cast will discuss the new world of weird and wild characters, show clips from the new series and answer questions from the audience.
The cult hit is available to download on the Apple iTunes Store. The free event starts at 7pm tonight.
Apple adds customers should arrive early, as seating is limited.
The Apple Store is located at 235 Regent Street, London, W1B 2EL, 020 7153 9000. The nearest tube station is Oxford Circus.